A highly water-soluble platinum(ii) complex containing a thiopropyl-1,2-dicarba-closo-dodecaborane(12) ligand functionalised with a pendant glycerol group.
نویسندگان
چکیده
Reaction of the novel thiopropyl-closo-1,2-carborane ligand bearing a pendant glycerol group HS(CH(2))(3)CB(10)H(10)CCH(2)OCH(CH(2)OH)(2)(L) with the labile platinum(ii) precursor [Pt(MeCN)(terpy)](OTf)(2)(terpy = 2,2':6',2''-terpyridine; OTf = trifluoromethanesulfonate) affords the highly water-soluble platinum(ii) complex [PtL(terpy)]OTf, the first example of a metal-carborane complex functionalised with a water-solubilising glycerol group.
منابع مشابه
Synthesis and anti-cancer activity of dinuclear platinum(II) complexes containing bis(thioalkyl)dicarba-closo-dodecaborane(12) ligands.
A series of novel, dinuclear (2,2':6',2''-terpyridine)platinum(ii) complexes containing bis(thioalkyl)-dicarba-closo-dodecaborane(12)(carborane) ligands were prepared and characterised, and their preliminary anti-cancer characteristics have been determined in vitro; the complexes are the first examples of bis-intercalator complexes containing a boron-rich carborane cage.
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The reaction of 1,2-bis(N,N-dimethylaminochloro-phosphanyl)-1,2-dicarba-closo-dodecaborane(12) and lithiated phenylacetylene gives a five-membered dihydrophosphole derivative with an exocyclic phosphanyl group. This unexpected reaction opens new possibilities for the synthesis of carbaborane-containing phosphorus heterocycles. P,P'-alkynylated 1,2-bis(phosphanyl)-1,2-dicarba-closo-dodecaborane(...
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In the title compound, 1,2-(SCH3)2-1,2-closo-C2B10H10 or C4H16B10S2, the methylsulfanyl groups are bonded to the C atoms of the 1,2-dicarba-closo-dodecaborane cage. The Ccage-Ccage distance is 1.8033 (18) A and the S-Ccage-Ccage-S torsion angle is 1.07 (13) degrees. The Ccage-Ccage distance is compared with those in other 1,2-dicarba-closo-dodecaborane derivatives.
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A series of stable platinum complexes containing closo-carborane cages in a 'carrier group', which could be potentially utilized for boron neutron capture therapy (BNCT), was successfully synthesized and characterized by various spectroscopic methods. Two ortho-closo-carborane cages were connected to the 3,3' or 4,4'-positions of 2,2'-bipyridine through ester bonds to give three carborane-linke...
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Experimental data on the mutual rearrangements of isomeric dicarba-closododecaboranes(12) and their B-halogen derivatives are reviewed. Reactions involving electron transfer to dicarba-closo-dodecaboranes(12), and the properties of the resulting dodecahydrodicarba-nido-dodecaborates(2 —) as intermediates of the rearrangements of 1.7and 1,12-dicarba-closo-dodecaboranes(12) are discussed. Attenti...
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ورودعنوان ژورنال:
- Dalton transactions
دوره 17 شماره
صفحات -
تاریخ انتشار 2005